AREDS2 supplements cut advanced AMD risk by 25%—but have side effects

Research has shown that certain supplements can slow the progression of age-related macular degeneration (AMD). The Age-Related Eye Disease Study (AREDS) first proved that high levels of antioxidants and zinc reduce the risk of advanced AMD. A later version, AREDS2, builds on this with additional benefits for vision health. The original AREDS study found that a combination of antioxidants and zinc lowered the risk of advanced AMD. AREDS2 improved on this formula by adding lutein and zeaxanthin. This updated version has been found to reduce the risk of progression from intermediate to advanced AMD by about 25%.

AREDS2 also cuts the risk of late-stage AMD by 18% compared to the original formula. It helps preserve vision longer and lowers the chance of severe central vision loss. Doctors now recommend AREDS2 for smokers, as the original AREDS formula carried a higher risk of lung cancer.

However, AREDS2 is not without side effects. Some users report mild digestive issues like stomach cramps, nausea, or changes in bowel movements. High zinc levels in the supplement can also lead to copper deficiency. Additionally, high vitamin E content may increase bleeding risk. AREDS2 supplements are available for those with intermediate or advanced AMD. They offer a more effective way to slow disease progression and protect vision. Yet, users should be aware of potential side effects and consult a doctor before starting the treatment.