First-Ever Mirror-Anatomy Heart and Liver Transplant Succeeds in Turin

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First-Ever Mirror-Anatomy Heart and Liver Transplant Succeeds in Turin

A 32-year-old man from Campania has become the first person to receive a combined heart and liver transplant despite having an extremely rare condition. His internal organs are a complete mirror image of normal anatomy, a disorder known as situs viscerum inversus. The groundbreaking surgery took place in February 2024 at Turin's Molinette Hospital.

The patient was born with severe congenital heart disease, which led to three open-heart surgeries over his lifetime. His heart condition later caused liver cirrhosis, which then developed into liver cancer. By early 2024, a combined heart-liver transplant became his only chance for survival.

A multidisciplinary team at Città della Salute in Turin took on the case after doctors in Campania referred him. The operation presented an extraordinary technical challenge: transplanting normally positioned donor organs into a body with mirrored anatomy. To prepare, a multi-specialty team travelled to the donor's hospital to retrieve the heart-liver block. They maintained constant communication with the transplant team at Molinette throughout the process.

The procedure required immense coordination, involving dozens of healthcare professionals. Since this pioneering surgery, only one other similar operation has been recorded worldwide by February 2026, making it an exceptionally rare medical achievement.

The successful transplant offers a lifeline for patients with situs viscerum inversus who require multi-organ procedures. As of early 2026, no further cases of this kind have been reported, leaving the Turin operation as one of the few of its type ever performed.

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First-Ever Mirror-Anatomy Heart and Liver Transplant Succeeds in Turin

First-Ever Mirror-Anatomy Heart and Liver Transplant Succeeds in Turin